張翱

人物履歷

1988 年 9 月至 1992 年 7 月，就讀于四川師范學(xué)院（現(xiàn)西華師范大學(xué)）化學(xué)系，獲學(xué)士學(xué)位； 1992 年 9 月至 1995 年 7 月，就讀于南開大學(xué)元素有機(jī)化學(xué)研究所，獲碩士學(xué)位； 1997 年 10 月至 2000 年 10 月，中科院上海有機(jī)化學(xué)研究所，獲博士學(xué)位，導(dǎo)師為姜標(biāo)研究員。 1995 年 7 至 1997 年 9 月，在中科院上海有機(jī)化學(xué)研究所工作，任研究實(shí)習(xí)員。 2001 年 2 月至 2002 年 3 月，在美國(guó)喬治敦大學(xué)（ Georgetown University ） 醫(yī)藥中心作博士后訪問學(xué)者； 2002 年 4 月至 2006 年 2 月，在美國(guó)哈佛大學(xué)（ Harvard University ）醫(yī)學(xué)院工作，任哈佛醫(yī)學(xué)院 Instructor ， McLean Hospital 藥物化學(xué)研究室 Assistant Director ， 美國(guó)化學(xué)會(huì)東北分會(huì)會(huì)刊《 The Nucleus 》副編輯； 2006 年至今在中國(guó)科學(xué)院上海藥物研究所工作，獲中科院 " 百人計(jì)劃 " 擇優(yōu)支持。

研究方向

張翱研究組主要從事創(chuàng)新藥物研發(fā)及相關(guān)基礎(chǔ)研究，尤其是靶向G-蛋白偶聯(lián)受體（GPCR）和酪氨酸激酶（RTK）新型小分子藥物的設(shè)計(jì)與合成研究。主要是通過發(fā)展新穎簡(jiǎn)捷合成方法實(shí)現(xiàn)類藥性優(yōu)勢(shì)骨架的高效合成，以及基于活性天然產(chǎn)物類藥性骨架進(jìn)行多樣性合成和衍生化，結(jié)合現(xiàn)代藥物結(jié)構(gòu)優(yōu)化策略，探索藥物的結(jié)構(gòu)與活性、結(jié)構(gòu)與靶向性、結(jié)構(gòu)與成藥性等規(guī)律，進(jìn)而開發(fā)具有抗神經(jīng)退行性疾病和抗腫瘤活性的新型藥物。研究組目前正在進(jìn)行的研究課題主要有： 【1】具有抗腫瘤活性的類藥性天然產(chǎn)物的合成及基于成藥性的結(jié)構(gòu)優(yōu)化； 【2】靶向酪氨酸激酶或DNG修復(fù)等特異性或多靶性抑制劑抗腫瘤藥物的設(shè)計(jì)與合成； 【3】靶向G-蛋白偶聯(lián)受體小分子藥物的設(shè)計(jì)及抗神經(jīng)退行性疾病活性研究。

專家類別

研究員；百人計(jì)劃；國(guó)家杰出青年

職務(wù)

中科院上海藥物所研究員、博士生導(dǎo)師、研究組長(zhǎng)

獲獎(jiǎng)及榮譽(yù)

2004年獲哈佛醫(yī)學(xué)院McLean Hospital年度最高學(xué)術(shù)獎(jiǎng)-A LFRED POPE AWARD；同年還獲得哈佛醫(yī)學(xué)院 McLean Hospital - ADAM CORNEEL YOUNG INVESTIGATOR AWARD；2010年獲中科院“百人計(jì)劃”終期評(píng)估優(yōu)秀獎(jiǎng)；2011年獲國(guó)家杰出青年基金。

代表論著

1、SELECTED PUBLICATIONS Chengtang Du, Fulong Li, Xuefeng Zhang, Wenxiang Hu, Qizheng Yao, Ao Zhang. Lewis Acid-Catalyzed Cyclization of Glycals/2-deoxy-D-ribose with Aryl Amines: Additional Findings on Product Structure and Reaction Diastereoselectivity. J. Org. Chem Jun Sun, Xuefeng Zhang, Fulong Li, Chunyong Ding, Wenjuan Wu, Ao Zhang. Base-promoted reaction of methyl 4,6-O-benzylidene-3-deoxy-hexopyranosid-2-ulose and various arylamines Tetrahedron Lett. Yuanxiang Wang, Jing Ai, Gang Liu, Meiyu Geng, Ao Zhang. Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors. Org. Biomol. Chem Hai Zhang, Na Ye, Shanglin Zhou, Lin Guo, Longtai Zheng, Zhili Liu, Bo Gao, Xuechu Zhen, and Ao Zhang: Identification of N-Propylnoraporphin-11-yl 5-(1,2-Dithiolan-3-yl)pentanoate as a New Anti-Parkinson's Agent Possessing a Dopamine D2 and Serotonin 5-HT1A Dual-Agonist Profile. J. Med. Chem Ailing Zhao, Xin Gao, Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Meiyu Geng, Ao Zhang: Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold. Bioorg. Med. Chem Zhiqing Liu, Qingzhang Zhu, Fuying Li, Lina Zhang, Ying Leng, Ao Zhang: N-(5-Substituted Thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) Propanamides as Glucokinase Activators. MedChemComm Fulong Li, Chunyong Ding, Meining Wang, Qizheng Yao, Ao Zhang: InBr3-Catalyzed Glycosidation of Glycals with Arylamines: An Alternative Approach To Access 4-Aminocyclopent-2-enones. J. Org. Chem Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Lu Wang, Gang Liu, Meiyu Geng, Ao Zhang: Synthesis and c-Met kinase inhibition of 3,5-di- and 3,5,7-tri- substituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)- 5-(3-nitrobenzylamino)- 7- (trifluoromethyl)quinoline as a novel anticancer agent. J. Med. Chem Na Ye, QianQian Wu, Liyuan Zhu, Longtai Zheng, Bo Gao, Xuechu Zhen, Ao Zhang: Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands. Bioorg. Med. Chem. Jing Zhang, Kui Wu, Meining Wang, Jianqin Jiang, Ao Zhang: FeCl3.6H2O-promoted skeleton-rearrangement of 1-substituted-3-benzazepines: substrate extension and product utilization. Tetrahedron Tu, S.; Ding, C.; Hu, W.; Li, F.; Yao, Q.; Zhang A. Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence. Mol Divers Fuying Li, Qingzhang Zhu, Yi Zhang, Ying Feng, Ying Leng, Ao Zhang: Design, synthesis and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators. Bioorg. Med. Chem Chunyong Ding, Shanghui Tu, Qizheng Yao, Fulong Li, Yuanxiang Wang, Wenxiang Hu, Ao Zhang: One-Pot Three-step Synthesis of Naphtho [2,3-a]carbazole-5,13-diones Using Tandem Radical Alkylation-Cyclization -Aromatization Reaction Sequence. Adv Syn Catal Zhili Liu, Hai Zhang, Na Ye, Jing Zhang, QianQian Wu, Peihua Sun, Linyong Li, Xuechu Zhen, and Ao Zhang: Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1A Receptor Agonist. J. Med. Chem Yi Zhang, Zhaobin Han, Fuying Li, Kuiling Ding and Ao Zhang: Highly enantioselective hydrogenation of a-aryl-b-substituted acrylic acids catalyzed by Ir-SpinPHOX. Chem. Commun Jing Zhang, Ao Zhang: Unprecedented FeCl3·6H2O-Promoted Skeleton-Rearrangement of 1-Aryl-2,3,4,5-tetrahydro-1H-3-benzazepines: a New Strategy for the Synthesis of C-1 Quaternary Tetrahydroisoquinolines. Chem. Eur. J Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Xin Xie, Ao Zhang: [6,7]-Heterocycle-Fused 14-Hydroxymorphinan Derivatives: Design, Synthesis, and Opioid Receptor Activity. ChemMedChem Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Xin Xie, Ao Zhang: Synthesis and SAR study of opioid receptor ligands: momo- and bis-indolomorphinans. Chem Biol Drug De Chunyong Ding, Shanghui Tu, Fuying Li, Yuanxiang Wang, Qizheng Yao, Wenxiang Hu, Hua Xie, Linghua Meng, Ao Zhang: Synthesis Study on Marmycin A: Preparation of the C3’-Desmethyl Analogues. J. Org. Chem Yuanxiang Wang, Ao Zhang: Expeditious synthesis of 2,3-dihydro-2-alkoxy-3-methylenebenzofurans from N-benzofuran-3-ylmethyl N,N,N-trialkylammonium bromides. Tetrahedron Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Ao Zhang: Synthesis and opioid receptor activity of indolopropellanes. Bioorg. Med. Chem. Lett Jing Zhang, Hai Zhang, Wenxian Cai, Leiping Yu, Xuechu Zhen, Ao Zhang: “Click” D1 receptor agonists with a 5-HT1A receptor pharmacophore producing D2 receptor activity. Bioorg. Med. Chem Xue-Qin Chen, Jing Zhang, John L. Neumeyer, Guo-Zhang Jin, Guo-Yuan Hu, Ao Zhang, Xuechu Zhen: Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects. PLoS One Yu-Jun Wang, Yi-Min Tao, Fu-Ying Li, Yu-Hua Wang, Xue-Jun Xu, Jie Chen, Ying-Lin Cao, Zhi-Qiang Chi, John L. Neumeyer, Ao Zhang, and Jing-Gen Liu: Pharmacological Characterization of ATPM, a Novel Mixed Agonist and μ Agonist/Antagonist That Attenuates Morphine Antinociceptive Tolerance and Heroin Self-Administration Behavior. J. Pharm. Exp. Ther Zhili Li, Jing Zhang, Ao Zhang: Design of multivalent ligand targeting g-protein-coupled receptors.Curr Pharm Des Jing Zhang, Bing Xiong, Xuechu Zhen, Ao Zhang: Dopamine D1 receptor ligands: Where are we now and where are we going, Med. Res. Rev